• 2015
  • The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer.

    Greg Shaw, Hayley Whitaker; Marie Corcoran; Mark Dunning; Jonathan Kay; Hayley Luxton; Charlie Massie; Miller Jodi; Alastair Lamb; Helen Ross-Adams; Roslin Russell; Adam Nelson; Matthew Eldridge; Andrew Lynch; Antonio Ramos-Montoya; Ian Mills; Angela Taylor; Wiebke Arlt; Nimish Shah; Anne Warren; David Neal.  European Urology. Aug;70(2):214-8 PMID:26572708.

     

    Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study.

    H. Ross-Adams, A.D. Lamb, M.J. Dunning, S. Halim, J. Lindberg, C.M. Massie, L.A. Egevad, R. Russell, A. Ramos-Montoya, S.L. Vowler, N.L. Sharma, J. Kay, H. Whitaker, J. Clark, R. Hurst, V.J. Gnanapragasam, N.C. Shah, A.Y. Warren, C.S. Cooper, A.G. Lynch, R. Stark, I.G. Mills, H. Grönberg, D.E. Neal. EBioMedicine, 29 July 2015 PMID:26501111

     

    HES5 silencing early in prostate tumourigenesis highlights a transcriptional network involving the AR, HES transcription factors and TMPRSS2-ERG gene fusions.

    Charles E Massie, Inmaculada Spiteri, Helen Ross-Adams, Hayley Luxton, Jonathan Kay, Hayley C. Whitaker, Mark Dunning, Alastair D Lamb, Antonio Ramos-Montoya, Daniel Brewer, Colin S. Cooper, Rosalind Eeles, Ultan McDermott, UK Prostate ICGC Group, Anne Warren, Simon Tavaré, David E. Neal and Andrew G Lynch. Endocrine Related Cancer, 2015, Apr;22(2):131-44. PMID:25560400

     

    The Evolutionary History of Lethal Metastatic Prostate Cancer.

    Gunes Gundem, Peter Van Loo, Barbara Kremeyer, Ludmil B. Alexandrov, Jose Tubio, Elli Papaemmanuil, Daniel S. Brewer, Heini M.L. Kallio, Gunilla Högnäs, Matti Annala, Victoria Goody, Calli Latimer, Sarah O’Meara, Kevin J. Dawson, William Isaacs, Michael R Emmert-Buck, Matti Nykter, Christopher Foster, Zsofia Kote-Jarai, Douglas Easton, Hayley Whitaker, David E. Neal, Colin Cooper, Rosalind A. Eeles, Tapio Visakorpi, Peter J. Campbell, Ultan McDermott, David C. Wedge and G. Steven Bova. Nature 2015 Apr 16;520(7547):353-7. PMID: 25830880.

     

    Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer.

    Pertega-Gomes N, Vizcaino JR, Felisbino S, Warren AY, Shaw G, Kay J, Whitaker H, Lynch AG, Fryer L, Neal DE, Massie CE. Oncotarget. 2015 Jun 2 PMID: 26035357

     

    Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

    Cooper CS , Eeles R, Wedge DC, Van Loo P, Gundem G, Alexandrov LB, Kremeyer B, Butler A, Lynch AG, Camacho N, Massie CE, Kay J, Luxton HJ, Edwards S, Kote-Jarai Z, Dennis N, Merson S, Leongamornlert D, Zamora J, Corbishley C, Thomas S, Nik-Zainal S, O'Meara S, Matthews L, Clark J, Hurst R, Mithen R, Bristow RG, Boutros PC, Fraser M, Cooke S, Raine K, Jones D, Menzies A, Stebbings L, Hinton J, Teague J, McLaren S, Mudie L, Hardy C, Anderson E, Joseph O, Goody V, Robinson B, Maddison M, Gamble S, Greenman C, Berney D, Hazell S, Livni N; the ICGC Prostate Group, Fisher C, Ogden C, Kumar P, Thompson A, Woodhouse C, Nicol D, Mayer E, Dudderidge T, Shah NC, Gnanapragasam V, Voet T, Campbell P, Futreal A, Easton D, Warren AY, Foster CS, Stratton MR, Whitaker HC, McDermott U, Brewer DS, Neal DE. Nature Genetics Mar 2 2015 doi:10.1038/ng.3221 PMID: 25730763

  • 2014
  • The landscape of mitochondrial DNA mutations in human cancer. Young Seok Ju, Ludmil B Alexandrov, Moritz Gerstung, Inigo Martincorena, Serena Nik-Zainal, Manasa Ramakrishna, Helen R Davies, Elli, Papaemmanuil, Gunes Gundem, Adam Shlien, Niccolo Bolli, Sam Behjati, Patrick S Tarpey, Jyoti Nangalia, Charles E Massie, Adam P Butler, Jon W Teague, George S Vassiliou, Anthony R Green, Ming-Qing Du, Ashwin Unnikrishnan, John E Pimanda, Bin Tean The, Nikhil Munshi, Mel Greaves, Paresh Vyas, Adel K El-Naggar, Tom Santarius, V Peter Collins, Richard Grundy, Jack A Taylor, D Neil Hayes, David Malkin, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Christopher Foster, Anne Y Warren, Hayley Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Tapio Visakorpi, William B Isaacs, G Steven Bova, Adrienne M Flanagan, P Andrew Futreal, Andy G Lynch, Ultan McDermott,  Michael R Stratton, Peter J Campbell. eLife 2014 Oct 1 (3). PMID: 25271376.

     

    Extensive transduction of non-repetitive DNA mediated by L1 retrotransposition in cancer genomes. Jose M. C. Tubio, Yilong Li, Young Seok Ju, Inigo Martincorena, Susanna L. Cooke, Marta Tojo, Gunes Gundem, Christodoulos P. Pipinikas, Jorge Zamora, Keiran Raine, Andrew Menzies, Pablo Roman-Garcia, Moritz Gerstung, Adam Shlien, Patrick S. Tarpey, Elli Papaemmanuil, Stian Knappskog, Peter Van Loo, Manasa Ramakrishna, Helen R. Davies, John Marshall, David C. Wedge, Jon W. Teague, Adam P. Butler, Serena Nik-Zainal, Sam Behjati, Lucy R. Yates, Niccolo Bolli, Laura Mudie, Claire Hardy, Sancha Martin, Stuart McLaren, ICGC Breast Cancer Group, ICGC Bone Cancer Group, ICGC Prostate Cancer Group, Christopher Foster, Anne Y Warren, Hayley Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Andy G. Lynch, Tapio Visakorpi, William B. Isaacs, Laura van't Veer, Carlos Caldas, Christine Desmedt, Christos Sotiriou, Sam Aparicio, John A. Foekens, Jórunn Erla Eyfjörd, Sunil R. Lakhani, Gilles Thomas, Ola Myklebost, Paul N. Span, Anne-Lise Børresen-Dale, Andrea L. Richardson, Marc van de Vijver, Anne Vincent-Salomon, Gert G. van den Eynden, Adrienne M. Flanagan, P. Andrew Futreal, Sam M. Janes, G. Steven Bova, Michael R. Stratton, Ultan McDermott, Peter J Campbell. Science 2014 345(6196) 1251434. PMID: 25082706.

     

    Luxton HJ, Barnouin K, Kelly G, Hanrahan S, Totty N, Neal DE, Whitaker HC. Regulation of the localisation and function of the oncogene LYRIC/AEG-1 by ubiquitination at K486 and K491. Mol Oncol. 2014 May;8(3):633-41. doi: 10.1016/j.molonc.2014.01.009. Epub 2014 Jan 24. PubMed PMID: 24529480; PubMed Central PMCID: PMC4013555.

     

    Allen MD, Luong P, Hudson C, Leyton J, Delage B, Ghazaly E, Cutts R, Yuan M, Syed N, Lo Nigro C, Lattanzio L, Chmielewska-Kassassir M, Tomlinson I, Roylance R, Whitaker HC, Warren AY, Neal D, Frezza C, Beltran L, Jones LJ, Chelala C, Wu BW, Bomalaski JS, Jackson RC, Lu YJ, Crook T, Lemoine NR, Mather S, Foster J, Sosabowski J, Avril N, Li CF, Szlosarek PW. Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging. Cancer Res. 2014 Feb 1;74(3):896-907. doi: 10.1158/0008-5472.CAN-13-1702. Epub 2013 Nov 27. PubMed PMID: 24285724.

     

    The landscape of mitochondrial DNA mutations in human cancer. Young Seok Ju, Ludmil B Alexandrov, Moritz Gerstung, Inigo Martincorena, Serena Nik-Zainal, Manasa Ramakrishna, Helen R Davies, Elli, Papaemmanuil, Gunes Gundem, Adam Shlien, Niccolo Bolli, Sam Behjati, Patrick S Tarpey, Jyoti Nangalia, Charles E Massie, Adam P Butler, Jon W Teague, George S Vassiliou, Anthony R Green, Ming-Qing Du, Ashwin Unnikrishnan, John E Pimanda, Bin Tean The, Nikhil Munshi, Mel Greaves, Paresh Vyas, Adel K El-Naggar, Tom Santarius, V Peter Collins, Richard Grundy, Jack A Taylor, D Neil Hayes, David Malkin, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Christopher Foster, Anne Y Warren, Hayley Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Tapio Visakorpi, William B Isaacs, G Steven Bova, Adrienne M Flanagan, P Andrew Futreal, Andy G Lynch, Ultan McDermott, Michael R Stratton, Peter J Campbell. Accepted for publication in eLife.

     

    Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women. Linda E Kelemen, James D Brenton, Christine Parkinson, Hayley C. Whitaker, Anna Piskorz, Ilona Csizmadi, Paula J Robson. PLoS ONE, 2014, 9(5) e95642.

  • 2013
  • Whitaker HC, Shiong LL, Kay JD, Grönberg H, Warren AY, Seipel A, Wiklund F, Thomas B, Wiklund P, Miller JL, Menon S, Ramos-Montoya A, Vowler SL, Massie C, Egevad L, Neal DE. N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 is overexpressed in cancer and promotes a pro-migratory and pro-metastatic phenotype. Oncogene. 2013 Nov 18. doi: 10.1038/onc.2013.464. [Epub ahead of print] PubMed PMID: 24240687.

     

    Whitaker HC, Patel D, Howat WJ, Warren AY, Kay JD, Sangan T, Marioni JC, Mitchell J, Aldridge S, Luxton HJ, Massie C, Lynch AG, Neal DE. Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress. Br J Cancer. 2013 Aug 20;109(4):983-93. doi: 10.1038/bjc.2013.396. Epub 2013 Jul 23. PubMed PMID: 23880827; PubMed Central PMCID: PMC3749568.

     

    Warren AY, Whitaker HC, Haynes B, Sangan T, McDuffus LA, Kay JD, Neal DE. Method for sampling tissue for research which preserves pathological data in radical prostatectomy. Prostate. 2013 Jan;73(2):194-202. doi: 10.1002/pros.22556. Epub 2012 Jul 16. PubMed PMID: 22806573.

  • 2012
  • Reebye V, Querol Cano L, Lavery DN, Brooke GN, Powell SM, Chotai D, Walker MM, Whitaker HC, Wait R, Hurst HC, Bevan CL. Role of the HSP90-associated cochaperone p23 in enhancing activity of the androgen receptor and significance for prostate cancer. Mol Endocrinol. 2012 Oct;26(10):1694-706. Epub 2012 Aug 16. PubMed PMID: 22899854.

  • 2011
  • Morgan R, Boxall A, Bhatt A, Bailey M, Hindley R, Langley S, Whitaker HC, Neal DE, Ismail M, Whitaker H, Annels N, Michael A, Pandha H. Engrailed-2 (EN2): a tumor specific urinary biomarker for the early diagnosis of prostate cancer. Clin Cancer Res. 2011 Mar 1;17(5):1090-8. doi: 10.1158/1078-0432.CCR-10-2410. Epub 2011 Mar 1. PubMed PMID: 21364037.

  • 2010
  • Whitaker HC, Neal DE. RAS pathways in prostate cancer - mediators of hormone resistance? Curr Cancer Drug Targets. 2010 Dec;10(8):834-9. Review. PubMed PMID: 20718703.

     

    Whitaker HC, Kote-Jarai Z, Ross-Adams H, Warren AY, Burge J, George A, Bancroft E, Jhavar S, Leongamornlert D, Tymrakiewicz M, Saunders E, Page E, Mitra A, Mitchell G, Lindeman GJ, Evans DG, Blanco I, Mercer C, Rubinstein WS, Clowes V, Douglas F, Hodgson S, Walker L, Donaldson A, Izatt L, Dorkins H, Male A, Tucker K, Stapleton A, Lam J, Kirk J, Lilja H, Easton D; IMPACT Study Steering Committee; IMPACT Study Collaborators; UK GPCS Collaborators, Cooper C, Eeles R, Neal DE. The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine. PLoS One. 2010 Oct 13;5(10):e13363. doi: 10.1371/journal.pone.0013363. PubMed PMID: 20967219; PubMed Central PMCID: PMC2954177.

     

    Whitaker HC, Warren AY, Eeles R, Kote-Jarai Z, Neal DE. The potential value of microseminoprotein-beta as a prostate cancer biomarker and therapeutic target. Prostate. 2010 Feb 15;70(3):333-40. doi: 10.1002/pros.21059. Review. PubMed PMID: 19790236.

  • 2009
  • Thirkettle HJ, Mills IG, Whitaker HC, Neal DE. Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression. Oncogene. 2009 Oct 15;28(41):3663-70. doi: 10.1038/onc.2009.223. Epub 2009 Aug 3. PubMed PMID: 19648967.

     

    Thirkettle HJ, Girling J, Warren AY, Mills IG, Sahadevan K, Leung H, Hamdy F, Whitaker HC, Neal DE. LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals. Clin Cancer Res. 2009 May 1;15(9):3003-13. doi: 10.1158/1078-0432.CCR-08-2046. Epub 2009 Apr 21. PubMed PMID: 19383828.

  • 2008
  • Deeb A, Jääskeläinen J, Dattani M, Whitaker HC, Costigan C, Hughes IA. A novel mutation in the human androgen receptor suggests a regulatory role for the hinge region in amino-terminal and carboxy-terminal interactions. J Clin Endocrinol Metab. 2008 Oct;93(10):3691-6. doi: 10.1210/jc.2008-0737. Epub 2008 Aug 12. PubMed PMID: 18697867.

     

    Whitaker HC, Girling J, Warren AY, Leung H, Mills IG, Neal DE. Alterations in beta-catenin expression and localization in prostate cancer. Prostate. 2008 Aug 1;68(11):1196-205. doi: 10.1002/pros.20780. PubMed PMID: 18459111.

     

    Cutress ML, Whitaker HC, Mills IG, Stewart M, Neal DE. Structural basis for the nuclear import of the human androgen receptor. J Cell Sci. 2008 Apr 1;121(Pt 7):957-68. doi: 10.1242/jcs.022103. Epub 2008 Mar 4. PubMed PMID: 18319300.

  • 2007
  • Whitaker HC, Stanbury DP, Brinham C, Girling J, Hanrahan S, Totty N, Neal DE. Labeling and identification of LNCaP cell surface proteins: a pilot study. Prostate. 2007 Jun 15;67(9):943-54. PubMed PMID: 17440980.

     

    Girling JS, Whitaker HC, Mills IG, Neal DE. Pathogenesis of prostate cancer and hormone refractory prostate cancer. Indian J Urol. 2007 Jan;23(1):35-42. doi: 10.4103/0970-1591.30265. PubMed PMID: 19675761; PubMed Central PMCID: PMC2721494.

  • 2006 and earlier
  • Powell SM, Brooke GN, Whitaker HC, Reebye V, Gamble SC, Chotai D, Dart DA, Belandia B, Bevan CL. Mechanisms of androgen receptor repression in prostate cancer. Biochem Soc Trans. 2006 Dec;34(Pt 6):1124-7. PubMed PMID: 17073766.

     

    Whitaker HC, Hanrahan S, Totty N, Gamble SC, Waxman J, Cato AC, Hurst HC, Bevan CL. Androgen receptor is targeted to distinct subcellular compartments in response to different therapeutic antiandrogens. Clin Cancer Res. 2004 Nov 1;10(21):7392-401. PubMed PMID: 15534116.

     

    Roobol A, Grantham J, Whitaker HC, Carden MJ. Disassembly of the cytosolic chaperonin in mammalian cell extracts at intracellular levels of K+ and ATP. J Biol Chem. 1999 Jul 2;274(27):19220-7. PubMed PMID: 10383429.

Powell SM, Brooke GN, Whitaker HC, Reebye V, Gamble SC, Chotai D, Dart DA, Belandia B, Bevan CL. Mechanisms of androgen receptor repression in prostate cancer. Biochem Soc Trans. 2006 Dec;34(Pt 6):1124-7. PubMed PMID: 17073766.

 

Whitaker HC, Hanrahan S, Totty N, Gamble SC, Waxman J, Cato AC, Hurst HC, Bevan CL. Androgen receptor is targeted to distinct subcellular compartments in response to different therapeutic antiandrogens. Clin Cancer Res. 2004 Nov 1;10(21):7392-401. PubMed PMID: 15534116.

 

Roobol A, Grantham J, Whitaker HC, Carden MJ. Disassembly of the cytosolic chaperonin in mammalian cell extracts at intracellular levels of K+ and ATP. J Biol Chem. 1999 Jul 2;274(27):19220-7. PubMed PMID: 10383429.

Whitaker HC, Stanbury DP, Brinham C, Girling J, Hanrahan S, Totty N, Neal DE. Labeling and identification of LNCaP cell surface proteins: a pilot study. Prostate. 2007 Jun 15;67(9):943-54. PubMed PMID: 17440980.

 

Girling JS, Whitaker HC, Mills IG, Neal DE. Pathogenesis of prostate cancer and hormone refractory prostate cancer. Indian J Urol. 2007 Jan;23(1):35-42. doi: 10.4103/0970-1591.30265. PubMed PMID: 19675761; PubMed Central PMCID: PMC2721494.

Deeb A, Jääskeläinen J, Dattani M, Whitaker HC, Costigan C, Hughes IA. A novel mutation in the human androgen receptor suggests a regulatory role for the hinge region in amino-terminal and carboxy-terminal interactions. J Clin Endocrinol Metab. 2008 Oct;93(10):3691-6. doi: 10.1210/jc.2008-0737. Epub 2008 Aug 12. PubMed PMID: 18697867.

 

Whitaker HC, Girling J, Warren AY, Leung H, Mills IG, Neal DE. Alterations in beta-catenin expression and localization in prostate cancer. Prostate. 2008 Aug 1;68(11):1196-205. doi: 10.1002/pros.20780. PubMed PMID: 18459111.

 

Cutress ML, Whitaker HC, Mills IG, Stewart M, Neal DE. Structural basis for the nuclear import of the human androgen receptor. J Cell Sci. 2008 Apr 1;121(Pt 7):957-68. doi: 10.1242/jcs.022103. Epub 2008 Mar 4. PubMed PMID: 18319300.

Thirkettle HJ, Mills IG, Whitaker HC, Neal DE. Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression. Oncogene. 2009 Oct 15;28(41):3663-70. doi: 10.1038/onc.2009.223. Epub 2009 Aug 3. PubMed PMID: 19648967.

 

Thirkettle HJ, Girling J, Warren AY, Mills IG, Sahadevan K, Leung H, Hamdy F, Whitaker HC, Neal DE. LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals. Clin Cancer Res. 2009 May 1;15(9):3003-13. doi: 10.1158/1078-0432.CCR-08-2046. Epub 2009 Apr 21. PubMed PMID: 19383828.

Whitaker HC, Neal DE. RAS pathways in prostate cancer - mediators of hormone resistance? Curr Cancer Drug Targets. 2010 Dec;10(8):834-9. Review. PubMed PMID: 20718703.

 

Whitaker HC, Kote-Jarai Z, Ross-Adams H, Warren AY, Burge J, George A, Bancroft E, Jhavar S, Leongamornlert D, Tymrakiewicz M, Saunders E, Page E, Mitra A, Mitchell G, Lindeman GJ, Evans DG, Blanco I, Mercer C, Rubinstein WS, Clowes V, Douglas F, Hodgson S, Walker L, Donaldson A, Izatt L, Dorkins H, Male A, Tucker K, Stapleton A, Lam J, Kirk J, Lilja H, Easton D; IMPACT Study Steering Committee; IMPACT Study Collaborators; UK GPCS Collaborators, Cooper C, Eeles R, Neal DE. The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine. PLoS One. 2010 Oct 13;5(10):e13363. doi: 10.1371/journal.pone.0013363. PubMed PMID: 20967219; PubMed Central PMCID: PMC2954177.

 

Whitaker HC, Warren AY, Eeles R, Kote-Jarai Z, Neal DE. The potential value of microseminoprotein-beta as a prostate cancer biomarker and therapeutic target. Prostate. 2010 Feb 15;70(3):333-40. doi: 10.1002/pros.21059. Review. PubMed PMID: 19790236.

Morgan R, Boxall A, Bhatt A, Bailey M, Hindley R, Langley S, Whitaker HC, Neal DE, Ismail M, Whitaker H, Annels N, Michael A, Pandha H. Engrailed-2 (EN2): a tumor specific urinary biomarker for the early diagnosis of prostate cancer. Clin Cancer Res. 2011 Mar 1;17(5):1090-8. doi: 10.1158/1078-0432.CCR-10-2410. Epub 2011 Mar 1. PubMed PMID: 21364037.

Reebye V, Querol Cano L, Lavery DN, Brooke GN, Powell SM, Chotai D, Walker MM, Whitaker HC, Wait R, Hurst HC, Bevan CL. Role of the HSP90-associated cochaperone p23 in enhancing activity of the androgen receptor and significance for prostate cancer. Mol Endocrinol. 2012 Oct;26(10):1694-706. Epub 2012 Aug 16. PubMed PMID: 22899854.

Whitaker HC, Shiong LL, Kay JD, Grönberg H, Warren AY, Seipel A, Wiklund F, Thomas B, Wiklund P, Miller JL, Menon S, Ramos-Montoya A, Vowler SL, Massie C, Egevad L, Neal DE. N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 is overexpressed in cancer and promotes a pro-migratory and pro-metastatic phenotype. Oncogene. 2013 Nov 18. doi: 10.1038/onc.2013.464. [Epub ahead of print] PubMed PMID: 24240687.

 

Whitaker HC, Patel D, Howat WJ, Warren AY, Kay JD, Sangan T, Marioni JC, Mitchell J, Aldridge S, Luxton HJ, Massie C, Lynch AG, Neal DE. Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress. Br J Cancer. 2013 Aug 20;109(4):983-93. doi: 10.1038/bjc.2013.396. Epub 2013 Jul 23. PubMed PMID: 23880827; PubMed Central PMCID: PMC3749568.

 

Warren AY, Whitaker HC, Haynes B, Sangan T, McDuffus LA, Kay JD, Neal DE. Method for sampling tissue for research which preserves pathological data in radical prostatectomy. Prostate. 2013 Jan;73(2):194-202. doi: 10.1002/pros.22556. Epub 2012 Jul 16. PubMed PMID: 22806573.

The landscape of mitochondrial DNA mutations in human cancer. Young Seok Ju, Ludmil B Alexandrov, Moritz Gerstung, Inigo Martincorena, Serena Nik-Zainal, Manasa Ramakrishna, Helen R Davies, Elli, Papaemmanuil, Gunes Gundem, Adam Shlien, Niccolo Bolli, Sam Behjati, Patrick S Tarpey, Jyoti Nangalia, Charles E Massie, Adam P Butler, Jon W Teague, George S Vassiliou, Anthony R Green, Ming-Qing Du, Ashwin Unnikrishnan, John E Pimanda, Bin Tean The, Nikhil Munshi, Mel Greaves, Paresh Vyas, Adel K El-Naggar, Tom Santarius, V Peter Collins, Richard Grundy, Jack A Taylor, D Neil Hayes, David Malkin, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Christopher Foster, Anne Y Warren, Hayley Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Tapio Visakorpi, William B Isaacs, G Steven Bova, Adrienne M Flanagan, P Andrew Futreal, Andy G Lynch, Ultan McDermott,  Michael R Stratton, Peter J Campbell. eLife 2014 Oct 1 (3). PMID: 25271376.

 

Extensive transduction of non-repetitive DNA mediated by L1 retrotransposition in cancer genomes. Jose M. C. Tubio, Yilong Li, Young Seok Ju, Inigo Martincorena, Susanna L. Cooke, Marta Tojo, Gunes Gundem, Christodoulos P. Pipinikas, Jorge Zamora, Keiran Raine, Andrew Menzies, Pablo Roman-Garcia, Moritz Gerstung, Adam Shlien, Patrick S. Tarpey, Elli Papaemmanuil, Stian Knappskog, Peter Van Loo, Manasa Ramakrishna, Helen R. Davies, John Marshall, David C. Wedge, Jon W. Teague, Adam P. Butler, Serena Nik-Zainal, Sam Behjati, Lucy R. Yates, Niccolo Bolli, Laura Mudie, Claire Hardy, Sancha Martin, Stuart McLaren, ICGC Breast Cancer Group, ICGC Bone Cancer Group, ICGC Prostate Cancer Group, Christopher Foster, Anne Y Warren, Hayley Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Andy G. Lynch, Tapio Visakorpi, William B. Isaacs, Laura van't Veer, Carlos Caldas, Christine Desmedt, Christos Sotiriou, Sam Aparicio, John A. Foekens, Jórunn Erla Eyfjörd, Sunil R. Lakhani, Gilles Thomas, Ola Myklebost, Paul N. Span, Anne-Lise Børresen-Dale, Andrea L. Richardson, Marc van de Vijver, Anne Vincent-Salomon, Gert G. van den Eynden, Adrienne M. Flanagan, P. Andrew Futreal, Sam M. Janes, G. Steven Bova, Michael R. Stratton, Ultan McDermott, Peter J Campbell. Science 2014 345(6196) 1251434. PMID: 25082706.

 

Luxton HJ, Barnouin K, Kelly G, Hanrahan S, Totty N, Neal DE, Whitaker HC. Regulation of the localisation and function of the oncogene LYRIC/AEG-1 by ubiquitination at K486 and K491. Mol Oncol. 2014 May;8(3):633-41. doi: 10.1016/j.molonc.2014.01.009. Epub 2014 Jan 24. PubMed PMID: 24529480; PubMed Central PMCID: PMC4013555.

 

Allen MD, Luong P, Hudson C, Leyton J, Delage B, Ghazaly E, Cutts R, Yuan M, Syed N, Lo Nigro C, Lattanzio L, Chmielewska-Kassassir M, Tomlinson I, Roylance R, Whitaker HC, Warren AY, Neal D, Frezza C, Beltran L, Jones LJ, Chelala C, Wu BW, Bomalaski JS, Jackson RC, Lu YJ, Crook T, Lemoine NR, Mather S, Foster J, Sosabowski J, Avril N, Li CF, Szlosarek PW. Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging. Cancer Res. 2014 Feb 1;74(3):896-907. doi: 10.1158/0008-5472.CAN-13-1702. Epub 2013 Nov 27. PubMed PMID: 24285724.

 

The landscape of mitochondrial DNA mutations in human cancer. Young Seok Ju, Ludmil B Alexandrov, Moritz Gerstung, Inigo Martincorena, Serena Nik-Zainal, Manasa Ramakrishna, Helen R Davies, Elli, Papaemmanuil, Gunes Gundem, Adam Shlien, Niccolo Bolli, Sam Behjati, Patrick S Tarpey, Jyoti Nangalia, Charles E Massie, Adam P Butler, Jon W Teague, George S Vassiliou, Anthony R Green, Ming-Qing Du, Ashwin Unnikrishnan, John E Pimanda, Bin Tean The, Nikhil Munshi, Mel Greaves, Paresh Vyas, Adel K El-Naggar, Tom Santarius, V Peter Collins, Richard Grundy, Jack A Taylor, D Neil Hayes, David Malkin, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Christopher Foster, Anne Y Warren, Hayley Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Tapio Visakorpi, William B Isaacs, G Steven Bova, Adrienne M Flanagan, P Andrew Futreal, Andy G Lynch, Ultan McDermott, Michael R Stratton, Peter J Campbell. Accepted for publication in eLife.

 

Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women. Linda E Kelemen, James D Brenton, Christine Parkinson, Hayley C. Whitaker, Anna Piskorz, Ilona Csizmadi, Paula J Robson. PLoS ONE, 2014, 9(5) e95642.

The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer.

Greg Shaw, Hayley Whitaker; Marie Corcoran; Mark Dunning; Jonathan Kay; Hayley Luxton; Charlie Massie; Miller Jodi; Alastair Lamb; Helen Ross-Adams; Roslin Russell; Adam Nelson; Matthew Eldridge; Andrew Lynch; Antonio Ramos-Montoya; Ian Mills; Angela Taylor; Wiebke Arlt; Nimish Shah; Anne Warren; David Neal.  European Urology. Aug;70(2):214-8 PMID:26572708.

 

Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study.

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